The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb
نویسندگان
چکیده
منابع مشابه
The Mdm2 oncoprotein interacts with the cell fate regulator Numb.
The Mdm2 oncoprotein is a well-known inhibitor of the p53 tumor suppressor, but it may also possess p53-independent activities. In search of such p53-independent activities, the yeast two-hybrid screen was employed to identify Mdm2-binding proteins. We report that in vitro and in transfected cells, Mdm2 can associate with Numb, a protein involved in the determination of cell fate. This associat...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1998
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.18.7.3974